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03/05/2014

HIV-infected Persons Have Higher Rates of Cancer-Specific Mortality


As people living with HIV are getting older, their risk of non-HIV associated malignancies is rising. Dr Anna Coghill from the National Cancer Institute presented results from a study investigating cancer-related mortality among HIV-infected persons using data from the HIV/AIDS Cancer Match Study, which allows linkages between 14 HIV and cancer registries, 5 of which were included in this analysis. The analysis used Cox Proportional Hazards with HIV as a time-varying covariate and adjustment for age, sex, year of cancer diagnosis, and cancer stage. HIV-positive persons were more likely to be men, nonwhite and younger. For 9 of 14 cancers evaluated there was a statistically significant elevated cancer-specific mortality for HIV-infected persons. For example, HIV-infected persons were more likely to die from breast cancer (Hazard Ratio 2.71, 95%CI 2.10-3.50), colorectal cancer HR 1.50 (1.07-2.09) and lung cancer HR 1.28 (1.17-1.40). Two cancers without an increase in cancer-specific mortality were Hodgkins Lymphoma and Diffuse Large B-Cell lymphoma. It is not yet known if the elevated cancer-specific mortality is due to variations in cancer treatment or clinical and molecular tumor differences due to HIV.

Reference:
Coghill AE, Shiels MS, Engels EA. HIV and Elevated Cancer-Specific Mortality Following Cancer Diagnosis in the United States. Abstract 99. CROI 2014, Boston, MA, March 3-6, 2014.


Source: Reporting from Boston for PRN News: Anita Radix, MD