Biomedical Prevention for COVID-19: Vaccines, MABs and Lessons from HIVBiomedical Prevention for COVID-19: Vaccines, MABs and Lessons from HIV

Dr. Mark Mulligan, Director, NYU Langone Vaccine Center describes the current landscape of COVID vaccine research.

This program is up-to-the-minute with a focus on New York City’s current role in COVID prevention, the emerging science during this public health emergency, and how we can learn from our HIV experience to manage the current pandemic.

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COVID-19 Pandemic: Update, Successes and ChallengesCOVID-19 Pandemic: Update, Successes and Challenges

Lessons we have learned from the HIV response can guide us moving forward as the new COVID-19 pandemic continues to expand and evolve. In this program, Wafaa El-Sadr, well known for her innovative work in HIV here in New York and around the world, uses her rich background experience to examine the dynamics of COVID19, scrutinize the challenges and successes of the various responses so far, identify populations disproportionately affected, and anticipate future needs with a steady eye on the science, public health and healthcare systems necessary for a more effective response to this devastating new pandemic.

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Antiretroviral Therapy for Treatment and Prevention: Beyond Daily Oral Therapy - A New FrontierAntiretroviral Therapy for Treatment and Prevention: Beyond Daily Oral Therapy - A New Frontier

Please join us for a presentation by Dr. Markowitz on the current recommendations for cART, a review of recent long-acting cabotegravir and rilpivirine data, and the exciting use of broadly neutralizing antibodies in the treatment and prevention of HIV.

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HIV Prevention Outreach in the 2020s: Grindr™, Gonorrhea, and HIV PrEPHIV Prevention Outreach in the 2020s: Grindr™, Gonorrhea, and HIV PrEP

Do Grindr™  users take more risks? Are Grindr™ users more likely to serosort? Dr. Martin Hoenigl will answer these questions. He will also cover novel ways to use geosocial mobile apps to better reach marginalized populations at risk for HIV/STIs and to promote testing and PrEP use.

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COVID-19 epidemic in Europe: What have we learned? And does underlying HIV-infection make a difference?COVID-19 epidemic in Europe: What have we learned? And does underlying HIV-infection make a difference?

What European clinicians and researchers have recently learned in these unprecedented times is of critical importance to us now and may help us change future outcomes.

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Update on Immunization Recommendations for Adolescents and Adults With and At-risk for HIV DiseaseUpdate on Immunization Recommendations for Adolescents and Adults With and At-risk for HIV Disease

Are all your patients up to date on vaccines? In these troubled times of “vaccine hesitancy,” internet misinformation, and clinician burnout, it is important that we take the time to make sure all of our patients, especially those living with HIV or asking for PrEP, are up to date on all their vaccines. This presentation by Jane Zucker will give you the information you need to confidently inform and advise your patients about immunizations and get the job done right.

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Advances and Controversies in HIV Prevention and Treatment: Updates from ID Week 2019Advances and Controversies in HIV Prevention and Treatment: Updates from ID Week 2019

ID Week has a wider focus on infectious diseases than CROI or IAS, but there are important research data and clinical pearls of interest to all HIV clinicians, as Michelle Cespedes clearly demonstrates. So, for the latest information from ID Week on long-acting agents, two-drug therapies, clinical considerations in changing regimens, tailoring HIV treatment strategies to the unique needs of your patients, preventing transmission and ending the epidemic, don’t miss this engaging and important summary.

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Prevention and Early Detection of HPV-associated Anogenital Cancers in Women Living with HIVPrevention and Early Detection of HPV-associated Anogenital Cancers in Women Living with HIV

As the incidence of HPV-associated cervical cancer is declining, the incidence of anal cancer is rising in women. But the dangers of HPV-associated dysplasia do not stop with the cervix and anus-- we must also be aware of the ways that dysplasia and cancer can present in women with vulvar and perianal complaints, and what we can do to stop it. Don’t miss this important review by Elizabeth Stier on screening, diagnosis and treatment of HPV-related disease in the entire female anogenital tract.

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Update on Anal Cancer Prevention, Screening, Treatment and Observation in HIV MedicineUpdate on Anal Cancer Prevention, Screening, Treatment and Observation in HIV Medicine

The incidence of HPV-associated anal cancer has increased every year for the past decade, and so has mortality, especially in our patients living with HIV. But questions remain about how to best screen people at risk, and how to prevent progression from high-grade precancerous lesions to anal cancer. This comprehensive lecture by Stephen Goldstone discusses the known risk factors, existing preventive and diagnostic strategies, the associated medical controversies, and the ongoing research needed to safeguard our patients’ health and quality of life

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HCV and HIV in Persons Who Inject DrugsHCV and HIV in Persons Who Inject Drugs

If you are not already treating hepatitis C in your patients who may be injecting drugs, why not? What barriers are holding you back? This compelling presentation by Brianna Norton targets the evidence-based studies that address the fears and misconceptions as well as the safety, efficacy and cost-effeciency of HCV treatment, even in patients who continue to inject illicit drugs. It all boils down to harm reduction, getting serious about eliminating hepatitis C, and knowing that, just as with HIV, treatment of HCV prevents further transmissions. And you can do it!

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Broadly Neutralizing Antibodies for HIV Prevention, Therapy and CureBroadly Neutralizing Antibodies for HIV Prevention, Therapy and Cure

So just what are broadly neutralizing antibodies anyway? And why are bNAbs so promising for HIV prevention and treatment? This presentation by Marina Caskey, one of the most prominent researchers leading the way in this new field of immunotherapy, discusses their potential in prevention of HIV infection during sexual exposure or mother-to-child transmission, as alternatives or adjuncts to antiretroviral drug therapy in populations that face challenges in maintaining long-term compliance with daily ART regimens, as salvage therapy in individuals with multi-ARV resistance, and more. Don’t miss this exciting glimpse of what HIV treatment and prevention may look like in the future.

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Update from IAS-2019 Mexico City: Focus on HIV Treatment and PreventionUpdate from IAS-2019 Mexico City: Focus on HIV Treatment and Prevention

Every 2 years, the International AIDS Society (IAS) holds its Conference on HIV Science, and this time it was in Mexico City, with nearly 6000 people from 130 countries attended IAS 2019. With multiple tracks, over 90 sessions and 1300 abstracts, it is impossible to cover all the information presented, but in this program, Trip Gulick highlights new data from research pertinent to treatment initiation, maintenance therapy, switch studies, and new drugs in development, as well as prevention efforts including pre-exposure prophylaxis and vaccine development. So, if you want to stay up to date and know what is in the horizon, do not miss this important program.

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HIV Treatment in an Era of Polypharmacy: The Current and Future Challenges with Drug InteractionsHIV Treatment in an Era of Polypharmacy: The Current and Future Challenges with Drug Interactions

Are drug interactions still an HIV treatment issue in 2019? You bet they are, but how can we differentiate ARVs in terms of their mechanisms of action and interaction potential? And what commonly co-administered drugs, such as statins, psychotropics, proton pump inhibitors, steroids, and gender affirming hormones do we need to be on high-alert for? All this, plus interactions with recreational drugs, especially those used in chem-sex, are discussed. Don’t miss this important presentation by David Back, internationally recognized for his groundbreaking work in online interactive drug-drug interaction awareness. Your patients will thank you.

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The Changing Spectrum of Sexually Transmitted Infections in People With and At Risk for HIVThe Changing Spectrum of Sexually Transmitted Infections in People With and At Risk for HIV

The kinds of sexually transmitted infections as well as their optimal treatments, in our patient with or at risk for HIV, are evolving and increasingly problematic. Recently, there was another cluster of sexually transmitted cases of hepatitis A in NYC, multi-drug-resistant GC remains a threat, lymphogranuloma venereum is a treatment problem especially when it is rectal, and mycoplasma genitalium (MGen) is on the rise. Being up to date on the diagnosis and treatment of STIs, and what do do when treatment fails, is important not just for your patients’ well-being but for their partners as well. Don’t miss this important update by Anna Huang on the other STIs we are presently seeing in the era of U = U and PrEP, and what you need to know to more effectively interrupt their chains of transmission.

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HIV Testing in the Era of PrEPHIV Testing in the Era of PrEP

When you write an order for an HIV test, do you know what assay your facility or reference lab is using? And depending on what assay is being used, and whether the specimen is whole blood or plasma, how soon after exposure can HIV infection be detected? And how does this window of time to detection change in patients who do not take PrEP as prescribed, for one reason or another? Yes, it gets complicated. You probably ask yourself these questions every time you see somebody requesting PEP or PrEP, or struggling to answer these questions as accurately as you can when your patients ask you for your expert opinion. This presentation by Bernard Branson will help you understand the limitations and advantages of the various HIV tests currently available as well as new assays in the testing pipeline, so that you can answer all of these questions better, no matter who is asking.

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HIV and Organ Transplant: Successes, Challenges and New FrontiersHIV and Organ Transplant: Successes, Challenges and New Frontiers

With the success of antiretroviral therapy, our patients are approaching near-normal life-expectancy. But we are also seeing a higher risk for end-organ disease in our aging HIV patients, and greater need for organ transplants. Even with the addition of HIV-positive organ donors, what is the wait time for recipients most in need? If the organ donor also has hepatitis C, can transplantation to an HCV-negative donor still be safe? And the outcomes-- how are HIV-positive recipients of liver, kidney, heart and lung transplants doing, as compared to the general population? For answers to these questions and much more about HIV-positive transplant recipients and donors, do not miss this exciting and informative program by Sapna Mehta.

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Update on The Kidney in HIV Treatment and PreventionUpdate on The Kidney in HIV Treatment and Prevention

Whether we are initiating antiretroviral therapy for HIV infection or pre-exposure prophylaxis to prevent it, we must not forget to screen for underlying kidney disease, and to establish baselines from which nephrotoxicity secondary to treatment can be detected and managed. This presentation by Christina Wyatt is packed with clinical pearls that will help you screen and evaluate kidney disease in your patients, including changes secondary to ARV toxicities and comorbid conditions such as diabetes and/or hypertension, strategies to maintain kidney health, as well as management of patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD).

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Expanding HIV Prevention Choices: What’s on the Horizon?Expanding HIV Prevention Choices: What’s on the Horizon?

At the most recent HIV Research for Prevention (HIVR4P) convention in Madrid, advocates from around the world were marching and chanting in support for more choices in HIV prevention modalities. And the prevention pipeline is very interesting! This presentation by Craig Hendrix targets the drugs, delivery systems, safety and efficacy of agents currently used for PrEP in diverse populations, including cisgender and transgender women, as well as the many agents in development that will help you in your next conversation with a patient wishing or waiting for more prevention choices.

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Clinical Controversies in HIV Clinical Controversies in HIV

We are fortunate in HIV medicine to have robust treatment and prevention guidelines, but there is always room for improvement. The advances we continue to see are driven, in part, by the controversies surrounding optimal prevention, treatment and cure strategies as evidence-based outcomes are continually reassessed. So, don’t miss this up-to-date review of current controversies by Raj Gandhi, focusing on prevention, treatment, complications of treatment, and efforts to find a cure.

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Advances in the Treatment and Prevention of HIV Infection: CROI 2019, Focus on ARTAdvances in the Treatment and Prevention of HIV Infection: CROI 2019, Focus on ART

Every year the Conference on Retrovirology and Opportunistic Infections (CROI) is packed with important new information and this program focuses on the advances in antiretroviral therapy to improve standards of care and point the way to future advances through emerging research and drug development. Don’t miss this engaging review by Trip Gulick on CROI 2019 highlights in HIV cure, treatment strategies and drug resistance, new drugs and mechanisms of action, HIV prevention, and TB coinfection.

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Visualizing HIV Transmission and PreventionVisualizing HIV Transmission and Prevention

What happens after genital or anal exposure to HIV, and how fast can infection take hold? When and where can this infection be stopped after exposure and what is the virus doing during the eclipse and window periods before it can be detected in blood? In this thought-provoking program, Tom Hope will sharpen your view of pathogenesis with his research into the earliest events of HIV transmission and dissemination utilizing non-human primate mucosal-challenge models, human tissue explant cultures, whole animal PET/CT and PET/MRI imaging, and electron microscopy.

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ChemSex and HIV: An Holistic Approach to HIV Treatment and Prevention for Crystal Meth UsersChemSex and HIV: An Holistic Approach to HIV Treatment and Prevention for Crystal Meth Users

Internet hook-up trends for gay men, in combination with recreational drugs, including crystal meth, to decrease inhibitions and increase sexual pleasure, are the drivers of what has become known as chemsex. This phenomenon is not limited to the UK and Europe, where the term was first used—it is international in scope, including New York City, and can lead to substance use disorders and mental illness. Chemsex also greatly increases the risk for non-adherence to HIV medication, PrEP, and condom use, while elevating the risk for transmission of HIV and other sexually transmitted diseases. How can we understand and help in a non-judgmental way? This program by Drs. Vaty Poitevien and Pierre Arty tackles this important and too-often overlooked problem.

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Ending the HIV Epidemic by 2020: Are We Still on Track?Ending the HIV Epidemic by 2020: Are We Still on Track?

We are making great strides in New York to end the HIV epidemic, as this presention by Demetre Daskalakis demonstrates. But how are the demographics changing? What are the emerging disparities? And how can we address the evolving needs of New Yorkers who are newly infected or at ongoing risk for transmission in all of our diverse communities? Don’t miss this important presentation on where we stand and the problems we currently face in the struggle to end the HIV epidemic once and for ALL by the end of 2020.

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Therapeutic Strategies Aimed at Achieving Antiretroviral Drug-Free HIV RemissionTherapeutic Strategies Aimed at Achieving Antiretroviral Drug-Free HIV Remission

Achieving a scalable and broad-based cure for HIV-infected individuals is a daunting challenge, but Cure research is ongoing, including immune-based strategies that boost the host immune response against the virus. Clinical trials aimed at achieving ART-free HIV-remission will need to include placebo groups and analytical treatment interruption and plasma viremia as an end point. Don’t miss this important presentation on current Cure research and ways that you and your eligible patients may be able to contribute to the science by which research outcomes can be effectively measured.

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Update on HCV Management in People Living with HIV and Other Key PopulationsUpdate on HCV Management in People Living with HIV and Other Key Populations

The newer drugs we now have to treat Hepatitis C have never been more tolerable, efficacious, or easier to use. And better yet, they can be used safely in acute HCV, people who continue to inject drugs, and even in people with end-stage liver disease and cirrhosis. If you are not already treating your patients with HCV, now is the time to watch this exciting program by Kristen Marks, and consider expanding your practice to treat and cure your patients with hepatitis C. Yes, its curable, and you can do this!

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Lipodystrophy 20 Years after Initial Descriptions: Body Fat Changes in Persons Living with HIVLipodystrophy 20 Years after Initial Descriptions: Body Fat Changes in Persons Living with HIV

You may not be seeing facial lipoatrophy or buffalo humps like we did in the early years of HAART, but body fat changes persist now, even with newer regimens. In this program, Todd Brown discusses the past and present body fat changes in the long-term management of HIV disease, the critical importance of lifestyle changes for the management of liopohypertrophy and obesity in HIV, the risk and benefits of pharmacologic approaches to treatment, and research strategies to guide treatment in the future.

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Conference Updates from IDWeek in San Francisco and IAS in AmsterdamConference Updates from IDWeek in San Francisco and IAS in Amsterdam

The treatment and prevention of HIV disease, Hepatitis C and their myriad complications are constantly changing—and the evolution of state-of-the-art management is almost always forecasted by research presented at major scientific meetings both nationally and internationally. In this program, David Hardy targets some of the highlights from AIDS 2018, the International AIDS Society’s conference in Amsterdam, and IDWeek 2018, the Infectious Diseases Society of America’s annual conference. Don’t miss this important review on diverse topics of interest to our primary care audience.

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Immune Activation in Treated HIV Infection: Does It Still Matter?Immune Activation in Treated HIV Infection: Does It Still Matter?

Even with early initiation of combination antiretroviral therapy, there is still a gap in life expectancy between our HIV-positive and HIV-negative patients, and age-associated morbidities and multimorbidities are more common in people aging with HIV. Don’t miss this fascinating and clinically important presentation by Peter Hunt on the effects of immune activation in our patients aging with HIV, what life-style changes and anti-inflammatory drugs may be helpful, and research strategies targeting root causes of chronic inflammation that may help our patients age more normally with fewer complications in the future.

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What's New in Kaposi Sarcoma?What's New in Kaposi Sarcoma?

In the days before combination antiretroviral therapy, one of the most stigmatizing AIDS-defining complications of HIV disease was Kaposi Sarcoma (KS), caused by coinfection with Kaposi Sarcoma-associated Herpes Virus (KSHV), also known as Human Herpesvirus-8 (HHV-8). Thankfully, we see KS infrequently now, but still need to keep it in the back of our minds. KSHV infection is life-long, similar to other herpesviruses, and even though overall KSHV seroprevalence in the USA is less than 10%, it is much higher in HIV-negative MSM (20-30%) and even higher in HIV-positive MSM (30-60%). So what are the implications for these patient populations as they age? Don’t miss this important review by Susan Krown, a leader in KS diagnosis and treatment from the earliest days of the AIDS epidemic in NYC, who is still involved in the fight against KS internationally.

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Diagnosis and Treatment of Anal Cancer: High Cure Rates, but at What Cost?Diagnosis and Treatment of Anal Cancer: High Cure Rates, but at What Cost?

When anal cancer prevention efforts fail, or when initial physical exam and screening lead to the diagnosis of malignancy, what next? This presentation by Stephen Goldstone, a surgeon, and Peter Kozuck, an oncologist, will walk you through the typical and atypical presentations of anal cancer, standard approaches to therapy, post-treatment follow-up, and consequent morbidities that that your patients may face.

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Prevention of Anal Cancer in HIV-Positive Men and Women: An Evolving Landscape Prevention of Anal Cancer in HIV-Positive Men and Women: An Evolving Landscape

Current data shows that anal cancer is increasing in general population and will remain the most common preventable cancer in our HIV-positive patients. So, what can we do to help prevent HPV-associated anal cancer? The preventive HPV vaccine is safe and highly efficacious, but what about anal cancer prevention in our patients already infected with oncogenic strains of HPV? This presentation by Joel Palefsky will bring you up-to-date on all current prevention modalities, how to evaluate your patients at risk, efforts to block progression to cancer, and scientific advances that may help us improve screening and prevention moving forward.

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Update from IAS-Amsterdam: PART-1Update from IAS-Amsterdam: PART-1

In this program Trip Gulick discusses important events leading up to the International AIDS Society conference - AIDS 2018 - including the 2018 UNAIDS data report on the global AIDS response, the FDA approval of the first PI-based single-tablet regimen for HIV, and the publication in JAMA of the IAS-USA 2018 recommendations for antiretroviral treatment and prevention of HIV infection. With this background, Dr. Gulick proceeds to discuss highlights of the AIDS 2018 meeting in Amsterdam, including new research on HIV treatment initiation, HIV and TB coinfection, and HIV switch studies. Due to the length of this program, we have split this into two parts. Be sure to watch both!

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Update from IAS-Amsterdam: PART-2Update from IAS-Amsterdam: PART-2

In this continuation of highlights from AIDS 2018 in Amsterdam, Dr. Gulick finishes his review of HIV switch studies, and goes on to discuss drug toxicities, ARVs in pregnancy and pediatrics, drug resistance, PrEP, including important information for PrEP in trans women, and further efforts to discover a cure for HIV infection. Don’t miss either of the two parts of this important and exciting program!

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Elimination of Mother-to-Child Transmission of HIV: The Final Frontier?Elimination of Mother-to-Child Transmission of HIV: The Final Frontier?

Efforts to prevent mother-to-child transmission of HIV are the oldest and most successful examples of HIV prophylaxis, and a model for post-exposure prophylaxis and the expanded efforts we now have, such as Treatment as Prevention. But even though it is rare, we still see mother-to-child transmission of HIV, especially when mothers become acutely infected during pregnancy or while nursing. It is important to understand the deficiencies and oversights in routine standards of care, if we hope to finally reduce perinatal HIV infection to zero.

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Growing Up with HIV Growing Up with HIV

Growing up is always difficult. Remember? But growing up with perinatal HIV infection, adds new dimensions to the physical and psychosocial challenges that children face as they struggle simply to survive, and hopefully thrive. This important presentation by Elaine Abrams will help you identify interventions that may help you improve the outcomes of young people growing up with HIV and care for them with a deeper understanding when they transition to adult medical care.

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The World Within: The Microbiome and Mucosal Immunity in HIV MedicineThe World Within: The Microbiome and Mucosal Immunity in HIV Medicine

We hear more and more about the microbiome these days, but what impact does the microbiome have in people with or at risk for HIV infection? We know the gut lymphoid system is rapidly and permanently impaired by HIV, and chronic use of antiretroviral drugs for HIV and antibiotic prophylaxis against opportunistic infections can affect the gut, but need we be concerned about the microbiome? This fascinating program will help you understand what is presently known about the interplay of the bacterial microbiome and mucosal immunity, the resulting effects on HIV susceptibility and HIV-associated chronic inflammation, and the latest efforts to leverage the microbiome to prevent HIV transmission and improve health for those living with HIV.

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Hepatitis C Treatment in People Who Inject DrugsHepatitis C Treatment in People Who Inject Drugs

Injection drug use is a growing problem across the country, and a well-known risk for transmission of hepatitis C. But can HCV in our patients who continue to inject drugs be successfully be treated? Does HIV/HCV coinfection decrease the odds for success? Can they be re-infected with HCV once cured? Will treatment of HCV in in these patients help stop the HCV epidemic? Unlike HIV, HCV is now curable, but we will never end the HCV epidemic if we cannot adequately serve our most vulnerable populations. This important program grapples with the barriers, both real and imagined, that stand in our way.

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Expanding Your Competency at the Boundary of Behavioral Health and HIV MedicineExpanding Your Competency at the Boundary of Behavioral Health and HIV Medicine

As a medical provider, you can have a powerful impact on the behavioral health of your patients living with HIV, but you need to know how to sort out what is required and what is optional, and utilize practical behavioral strategies to evaluate and manage depression, anxiety and stress. This presentation by Dr. Francine Cournos is packed with clinical pearls that will help you serve your patients mental health needs more effectively, while preserving your own sanity.

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Confronting Mental Health Challenges in Our Efforts to End the HIV EpidemicConfronting Mental Health Challenges in Our Efforts to End the HIV Epidemic

If we do not address mental health issues at the primary care level, we are very unlikely to be able to bring an end to the HIV epidemic. Mental health problems contribute not only to HIV acquisition, but also to poorer outcomes at every step in the HIV treatment cascade. Since people living with HIV disease have significantly higher rates of mental health disorders than that of the general population, in this program, Dr. Robert Remien focuses on strategies we can use to integrate mental health assessment and treatment into routine HIV care. Only then will we be able to achieve our “90-90-90” and “EtE” goals.

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