Lipodystrophy 20 Years after Initial Descriptions: Body Fat Changes in Persons Living with HIV

Todd T. Brown, MD, PhD
Professor of Medicine and Epidemiology
Division of Endocrinology, Diabetes, and Metabolism
Johns Hopkins University, Baltimore, MD



CME VIDEOTop of page

About the Presenter: Top of page

Todd Brown is a Professor of Medicine and Epidemiology in the Division of Endocrinology, Diabetes, and Metabolism at Johns Hopkins University where he is also the primary endocrine consultant to the Johns Hopkins HIV Clinic. He is a graduate of Columbia University College of Physicians and Surgeons and the Johns Hopkins Bloomberg School of Public Health. He completed his clinical training at Georgetown University and Johns Hopkins. His research focuses on metabolic, endocrine, and skeletal abnormalities observed in HIV-infected patients, as related to aging. Dr. Brown is particularly interested in the aging-related outcomes of cardiovascular disease, fractures, and frailty in persons living with HIV. He is a co-investigator in the Multicenter AIDS Cohort Study and the AIDS Clinical Trial Group. In the MACS, he is the co-Principal Investigator of the Baltimore/Washington DC site and is the former chair of the Metabolic Working Group. In the ACTG, he has served in leadership positions on multiple observational and interventional studies, including a substudy of REPRIEVE, the large statin trial in low CVD risk, persons living with HIV. He is a member of the Organizing Committee of the International Workshop on Comorbidities and Adverse Drug Reactions in HIV, now in its 20th year. He has published over 170 articles and book chapters on endocrine and metabolic problems and their consequences in HIV-infected persons and has lectured internationally on these topics.

Learning Objectives: Top of page

At the completion of this educational session, learners will:
  • Understand how legacy effects of drugs used early in the HAART era may affect current health.
  • Know how body composition is impacted by ART initiation and what the consequences are.
  • Review the evidence that integrase inhibitors lead to weight gain.

CME Information: Top of page


This CME activity has approved for AMA PRA Category 1 Credit™ on November 13, 2018 and will terminate November 12, 2021.

The target audience is all physicians, NPs and PAs involved or interested in HIV education.

This online video and post-activity evaluation are one hour in length.
  • After you complete the video portion of this educational activity there will be a post-activity evaluation and quiz.
  • You must achieve at least 70% correct to receive your CME certificate.
  • If successful, you will be provided instructions to print your CME certificate at the completion of this activity.
  • Accreditation Statement:Top of page


    This activity has been planned and implemented in accordance with the accreditation requirements and policies of the of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Medical Society of the State of New York (MSSNY) and the Physicians’ Research Network (PRN). MSSNY is accredited by the ACCME to provide continuing medical education for physicians.

    The Medical Society of the State of New York designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with extent of their participation in the activity.

    Disclosure Statement: Top of page


    Policies and standards of MSSNY require that speakers and planners for CME activities disclose any relevant financial relationships they may have with commercial interests whose products, devices or services may be discussed in the content of a CME activity.
  • Dr. James Braun (Planner/Course Director) had no relevant financial relationships to disclose.
  • Dr. Todd T. Brown (Presenter) has had the following personal financial relationships in the past 12 months with manufacturers of the products or services that may be presented in this CME activity: Consultant to Gilead, Merck, ViiV, and Theratechnologies. Dr. Brown submit his slides in advance for adequate peer review, and will support his presentation and clinical recommendations with the best available evidence from the medical literature.
  • Financial Support: Top of page

    This PRN CME activity is funded in part by unrestricted educational grants from: Gilead Sciences; Janssen Therapeutics, a division of Janssen Products, LP; and Merck & Co.

    How to Obtain CME Credit: Top of page

    This program will soon be available for CME on the PRN Courses Page at the Clinical Education Initiative Website of the New York State Department of Health, and we will add the link here, as soon as this is available. PRN and the Medical Society of the State of New York (MSSNY) jointly sponsor PRN enduring materials for CME, and provide them at no cost to the AIDS Institute of the New York State Department of Health (NYSDOH) for broadcast through the CEI. We thank the NYSDOH for making our CME programs available to a wider audience, and hope you will also browse the many other educational opportunities offered by the CEI.

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